i2b2 Course

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i2b2 (Informatics for Integrating Biology and the Bedside)

This is the i2b2 system for the course BHIS 509: Informatics for the Clinical Investigator hosted by the Center for Research Informatics (CRI).

Login Instructions

  • A demo instance of i2b2 application has been configured for the course.
  • i2b2 application can be accessed at https://bhis509.cri.uic.edu/webclient/.
  • Enter your UIC Email ID and password provided to log in.
  • About i2b2

    i2b2 (Informatics for Integrating Biology and the Bedside, http://www.i2b2.org) was an NIH-supported National Center for Biomedical Computing that developed a scalable informatics framework designed for translational research. The i2b2 framework is based on the Research Patient Data Registry (RPDR) developed at Massachusetts General Hospital.
    This framework has a number of advantages, including extensive testing by the Partners Health System and Harvard faculty; an easily understood database schema; release under an open-source license; the existence of an organized users group to share information and applications; and the potential for translational research through collaboration and federated queries across other i2b2 institutions.
    i2b2 was designed primarily for cohort identification, allowing users to perform an enterprise-wide search on a de-identified repository to determine the existence of a set of patients meeting certain inclusion or exclusion criteria. The i2b2 framework is packaged with a query tool that allows the user to drag-and-drop search terms from a hierarchical ontology into a Venn diagram-like interface. Investigators can perform an initial analysis on the de-identified cohort and if the results are promising, they can request approval from the IRB for a fully identified extract.


    Q: What are the uses of i2b2?

    A: The i2b2 warehouse is best suited for tasks like clinical cohort identification, feasibility analysis for clinical trials, hypothesis generation and retrospective data analysis. Automated query tool will facilitate some of these functions, while others will require more of a manual process.

    Q: What data elements are available in i2b2?

    A: The following data components or domains are part of the i2b2 dataset:
    1. Demographics
    2. Diagnoses
    3. Procedures
    4. Medications
    5. Laboratory tests
    6. Providers
    7. Reports
    8. Visit Details

    Q: Which terminologies are currently used?

    A: The following table provides a list of the current terminologies/standards used in the data warehouse:
    Diagnoses: ICD-9, ICD-10; Procedures: ICD-9-Procedure; Medications: NDC; Laboratory tests: LOINC